theranostics prostate cancer

If you believe that you have a health problem, please consult your healthcare provider. Evaluation of bone metastatic burden by bone SPECT/CT in metastatic prostate cancer patients: defining threshold value for total bone uptake and assessment in radium-223 treated patients. Rapid modulation of PSMA expression by androgen deprivation: serial 68Ga-PSMA-11 PET in men with hormone-sensitive and castrate-resistant prostate cancer commencing androgen blockade. 21. Theranostics, 11 (2021), pp. 2022 Apr;63(4):591-597. doi: 10.2967/jnumed.121.262270. Kelly JM, Amor-Coarasa A, Ponnala S, Nikolopoulou A, Williams C Jr, Thiele NA, et al. (a) Patient #1s baseline 18F-NaFPET/CT demonstrates widespread osteoblastic metastases with high 18F-NaF uptake. 5 Molecular Imaging and Therapeutic Nuclear Medicine, Cancer Imaging, Prostate Cancer Theranostics and Imaging Centre of Excellence (ProsTIC), Peter MacCallum Cancer Centre, Melbourne, VIC, Australia Background: Lutetium-177 [ 177 Lu]-PSMA-617 is a targeted radioligand that binds to prostate-specific membrane antigen doi: 10.1146/annurev-med-062117-073027, 38. The implementation of theranostic approaches to characterize and personalize patient management is beginning to be realized for prostate cancer patients. doi: 10.1053/ctrv.2000.0210, 89. 8600 Rockville Pike According to Dr. David Hirsch, chief executive officer of Alpha-9, the $75 million in Series B financing will enable the company to bring its first five treatments into clinical trials with doi: 10.1007/s12149-019-01404-2, 52. Clin Cancer Res. Wieser G, Popp I, Rischke HC, Drendel V, Grosu AL, Bartholom M, et al. Yadav MP, Ballal S, Tripathi M, Damle NA, Sahoo RK, Seth A, et al. government site. 10. Anticancer Res. Unauthorized use of these marks is strictly prohibited. De Bari B, Mazzola R, Aiello D, Fersino S, Gregucci F, Alongi P, Nicodemo M, Cavalleri S, Salgarello M, Alongi F. Radiol Med. Eur J Nucl Med Mol Imaging. Metastatic prostate cancer is incurable, and novel methods to detect the disease earlier and to direct definitive treatment are needed. doi: 10.2967/jnumed.119.226381, 43. Ferdinandus J, Eppard E, Gaertner FC, Krpig S, Fimmers R, Yordanova A, et al. 2023 Feb 3;13(3):564. doi: 10.3390/diagnostics13030564. 2021 Sep 23;12:758219. doi: 10.3389/fphar.2021.758219. official website and that any information you provide is encrypted doi: 10.1089/cbr.2019.3308. Skeletal related events, bone metastasis and survival of prostate cancer: a population based cohort study in Denmark (1999 to 2007). Lutetium-177-PSMA-617 for Metastatic Castration-Resistant Prostate Cancer. Asian J Androl. The majority of response data for this agent have been accrued from retrospective trials that have shown efficacy in reducing PSA levels with manageable hematological, renal, and salivary gland toxicity (6369). Online ahead of print. (2008) 58:68794. doi: 10.1002/cncr.32072, 77. 2022 Nov 2;10(11):2787. doi: 10.3390/biomedicines10112787. Currently, bone-directed targeted alpha therapy with radium-223 ( 223 Ra) is the only theranostic agent proven to prolong The https:// ensures that you are connecting to the Recent approvals of several different pharmacological and radiological entities by the FDA/EMA, often for the same indications, underline the value for molecularly targeted imaging and therapeutics to guide and enhance patient outcomes. Among PET radiotracers, prostate-specific membrane antigen (PSMA)-based compounds in advanced PCa are the focus of a continuously growing interest, mostly due to their potential relevance as theranostic agents. PMC Approved beta particle-emitting agents for bone pain palliation are [89Sr]chloride and [153Sm]EDTMP, an ion and phosphonic acid ligand, respectively, which are taken up at or near sites of bone metastasis. WebProstate-specific membrane antigen (PSMA) theranostics has shown promising results in both diagnosis and treatment of prostate cancer and is becoming an increasingly important tool in the management of this disease. Characterization of bone metastases from rapid autopsies of prostate cancer patients. Lancet. 93. Is Your Fear of A Cancer Diagnosis Keeping You Away from the Doctor? Unable to load your collection due to an error, Unable to load your delegates due to an error. doi: 10.7150/thno.20586, 48. Tc-99m PSMA and Lu-177 PSMA Theranostic Pair in a Patient of Metastatic Castration Resistant Prostate Cancer. 2018 Sep;12(3):359-365. doi: 10.1097/SPC.0000000000000357. Flegar L, Thoduka SG, Librizzi D, Luster M, Zacharis A, Heers H, Eisenmenger N, Ahmadzadehfar H, Eiber M, Weber W, Groeben C, Huber J. Eur J Nucl Med Mol Imaging. Clin Cancer Res. WebTheranostics is a personalised approach to treating cancer using both therapy and diagnostics. Reduction in [18F]-FDHT uptake and a plateau, consistent with saturation of AR binding, can be quantitated directly on a lesional or patient basis (16, 24). 8600 Rockville Pike Eur J Nucl Med Mol Imaging. J Nucl Med. 177Lu-PSMA-617 radioligand therapy and outcome in patients with metastasized castration-resistant prostate cancer. doi: 10.1016/j.peptides.2015.04.026, 83. Figure 2. Advances in radionuclide production and availability, chemical synthesis, and clinical trial implementation are rapid and ongoing, and new tools and approaches will undoubtedly emerge in the near future. doi: 10.1634/theoncologist.2020-0028, 78. Mol Imaging Biol. PSMA; Prostate cancer; Prostate-specific membrane antigen; Theranostics. Touijer KA, Michaud L, Alvarez HAV, Gopalan A, Kossatz S, Gonen M, et al. Other preclinical trials are exploring the possibility of using newer ligands or radioisotopes to treat prostate cancer to increase the specificity and efficacy of this treatment. developed a 17-variable nomogram that predicts outcome after LuPSMA therapy. J Clin Oncol. Bone metastases occupy a nutrient-rich niche that enhances the treatment-resistant nature of disseminated tumor cells (89). (2014) 41:2093105. 20. PSMA-targeted radionuclide therapy of metastatic castration-resistant prostate cancer with 177Lu-labeled PSMA-617. Of course, it should be noted that rigorous, prospective, controlled and multi-center trials, and statistical analyses are required before we can be confident that these new tools provide real-world benefit for patients. 2017 Mar;64(1):52-60. doi: 10.1002/jmrs.227. Disclaimer. (2015) 72:12844. FOIA Cancer statistics, 2018. Even after applying exclusion criteria (e.g., liver metastasis <2.5 cm) based on CT/MRI findings, a significant proportion of patients in the experimental arm did not derive a clinical benefit from 177Lu-PSMA-617.2. Before Any patient with a Medicare card can come to Peter Mac for a second opinion about their prostate cancer treatment. Please enable it to take advantage of the complete set of features! Epub 2018 May 8. In: Pathology Reviews. Diagnostic PSMA Despite the number of existing treatment options, efforts with molecularly targeted radiotherapies are under intense, global, evaluation; as well as to use new imaging agents to better guide drug development and more accurately characterize disease. An official website of the United States government. Similarly, as seen in the VISION trial, relying on CT/MRI findings alone, does not minimize the proportion of non-responders. Radioligand theranostics (RLT) has shown enormous potential as a newly emerged approach for managing LC [ 23 ]. Bethesda, MD 20894, Web Policies Theranostics. Optimal uptake time, magnitude of tumor and background organ uptake, and imaging resolution are dependent on ligand and radionuclide. Evaluation of PSMA expression changes on PET/CT before and after initiation of novel antiandrogen drugs (enzalutamide or abiraterone) in metastatic castration-resistant prostate cancer patients. Leibowitz R, Davidson T, Gadot M, Aharon M, Malki A, Levartovsky M, Oedegaard C, Saad A, Sandler I, Ben-Haim S, Domachevsky L, Berger R. Oncologist. These features have been exploited in the clinical evaluation of next generation anti-androgens in early clinical trial to directly quantitate AR-blockade. (A) Adenocarcinoma arising in the prostate gland is the second most common cancer in males, and can be cured with local intervention if detected when still localized to the organ. This review summarizes current evidence of theranostics for patients with prostate cancer. Underlying Features of Prostate Cancer-Statistics, Risk Factors, and Emerging Methods for Its Diagnosis. Academic Facilities o Outline facilities for clinical and academic pursuit: Clinical Nuclear Medicine department of the Jewish General Hospital and Lady Davis research institute. Effects of RNA Binding Proteins on the Prognosis and Malignant Progression in Prostate Cancer. Epub 2019 Nov 15. A Retrospective Analysis of the Safety and Activity of Lutetium-177-Prostate-Specific Membrane Antigen Radionuclide Treatment in Older Patients with Metastatic Castration-Resistant Prostate Cancer. 8143-8151. Flegar L, Thoduka SG, Librizzi D, Luster M, Zacharis A, Heers H, Eisenmenger N, Ahmadzadehfar H, Eiber M, Weber W, Groeben C, Huber J. Eur J Nucl Med Mol Imaging. (2017) 58:3129. Contrasting patients with sequential 18F-NaF PET/CT before and after treatment with 223RaCl2. Can I get a second opinion about my prostate cancer treatment, and get this at Peter Mac. Targeting the androgen receptor pathway in castration-resistant prostate cancer: progresses and prospects. Bethesda, MD 20894, Web Policies WebExcited to share a presentation by Dr. Stephan Probst of the on PSMA Theranostics for Prostate Cancer! Targeting metastatic prostate cancer with radiolabeled monoclonal antibody J591 to the extracellular domain of prostate specific membrane antigen. Prostate-specific membrane antigen (PSMA), a protein, is highly expressed on prostate cancer cells. Recently developed, highly potent anti-androgen molecules can be employed to some effect, even in late-stage, castrate-resistant PCa [CRPC (11)]. Examples of, PSMA Targeted radiopharmaceuticals. Significant clinical results have so far been achieved with the subsequent use of radiolabeled PSMA ligands in the treatment of CRPC. While GRPR expression may not be as ubiquitous on prostate cancer cells as PSMA, there is no background target expression in the kidneys or salivary glands. (1995) 1:1828. In summary, PSMA theranostics is anticipated to be a transformative change in the care of men with prostate cancer. Current status of theranostics in prostate cancer("Prostanostics"). doi: 10.1007/s00109-015-1329-4, 90. National Library of Medicine Pathol Oncol Res. (2019) 60:158793. 2022 Nov 14;12(18):7804-7820. doi: 10.7150/thno.77279. Unable to load your collection due to an error, Unable to load your delegates due to an error. Mackay S, Hitefield NL, Oduor IO, Roberts AB, Burch TC, Lance RS, Cunningham TD, Troyer DA, Semmes OJ, Nyalwidhe JO. Nrgaard M, Jensen A, Jacobsen JB, Cetin K, Fryzek JP, Srensen HT. J Nucl Med. Siderophore Scaffold as Carrier for Antifungal Peptides in Therapy of. Advanced prostate cancer (PCa) is a prominent cause of cancer death in men; positron emission tomography (PET) imaging may play a relevant role in detecting metastases and thus allowing a more tailored therapy in these patients. (2011) 17:392432. Will GRPR compete with PSMA as a target in prostate cancer? New York, NY: Elsevier (2007). Tagawa ST, Vallabhajosula S, Christos PJ, Jhanwar YS, Batra JS, Lam L, et al. -. Larimer BM, Dubois F, Bloch E, Nesti S, Placzek M, Zadra G, et al. (2019) 213:27585. 177Lu-Labeled Prostate-Specific Membrane Antigen Radioligand Therapy of Metastatic Castration-Resistant Prostate Cancer: Safety and Efficacy. form UCLA have endorsed the use of an interim PET after 3 cycles of 177Lu-PSMA-617. Diagnostic PSMA Contemporary prostate cancer states and systemic treatments. (2017) 58:18834. Ideally, a new diagnostic and therapy (theranostic) will have the following qualities: It will be theranostic for all cancers (high sensitivity) It will not be theranostic of anything that isnt cancer (high specificity) In my previous article ( see this link ), we saw how PSMA heterogeneity can lead to treatment failure. 2019 Jan-Apr;22(1):6-9. doi: 10.1967/s002449910952. Long-Term Follow-up and Outcomes of Retreatment in an Expanded 50-Patient Single-Center Phase II Prospective Trial of, Ultrastructural Analysis of Cancer Cells Treated with the Radiopharmaceutical Radium Dichloride ([. The impact of PSMA-based PET/computed tomography imaging on treatment strategies and prognosis is promising, but still not unquestionably clear. (2008) 8:26878. The authors declare no conflict of interest relevant to this article. (1998) 82:225661. FOIA doi: 10.1007/s11307-015-0850-8, 41. Violet J, Sandhu S, Iravani A, Ferdinandus J, Thang SP, Kong G, Kumar AR, Akhurst T, Pattison DA, Beaulieu A, Mooi J, Tran B, Guo C, Kalff V, Murphy DG, Jackson P, Eu P, Scalzo M, Williams S, Hicks RJ, Hofman MS. J Nucl Med. WebFigure 2. Farolfi A, Fendler W, Iravani A, Haberkorn U, Hicks R, Herrmann K, Walz J, Fanti S. Eur Urol Oncol. Urol Case Rep. (2018) 16:868. International union of pharmacology. The https:// ensures that you are connecting to the Examples of diagnostic and therapeutic agents targeting Prostate Specific Membrane Antigen. I live outside of Victoria can I access this treatment in my state? (2018) 68:730. Logistical and cost issues are also a consideration. We then use Lutetium 177 PSMA to treat the cancer. Concurrent with the development of the PSMA-targeted diagnostic agents described above, the application of PSMA-directed targeted radiotherapy of PCa is an ongoing area of great potential. Raval A, Dan TD, Williams NL, Pridjian A, Den RB. This occurred even after patients were enrolled on the basis of a 68Ga-PSMA-11 scan showing high PSMA-expression (at least one site with SUVmax20) and an 18F-FDG demonstrating no sites of disease of FDG-positive and PSMA-negative (i.e., discordant) disease.1, A similar situation was observed in the VISION trial of 177Lu-PSMA-617 versus alternate ARPi in patients with PSMA-positive mCRPC who had previously received treatment with next-generation androgen receptor signaling inhibition (abiraterone, enzalutamide, etc) and one or two prior lines of taxane chemotherapy. doi: 10.18632/oncotarget.21600, 69. Pfitzenmaier J, Ellis WJ, Hawley S, Arfman EW, Klein JR, Lange PH, et al. Lutetium-177-conjugated PSMA-617 or PSMA-I&T (Lu-PSMA) has shown promising results in multicenter retrospective and monocenter prospective trials. (2015) 93:120312. Alpha-particle emitting Ac-225 bound to the DOTA chelator-bearing PSMA-617 scaffold was used to treat a patient following disease progression after several lines of conventional treatment and [177Lu]PSMA-617. Int J Radiat Oncol Biol Phys. Several completed trials of 177Lu-PSMA have demonstrated that this Theragnostic can increase overall survival in men with progressing castrate-resistant prostate cancer. Please enable it to take advantage of the complete set of features! (2019) 60:9504. (2020) 20200028. Current use and future potential of (physiologically based) pharmacokinetic modelling of radiopharmaceuticals: a review. However, studies to date generally lack rigorous patient enrollment and follow-up criteria and have not followed patients for long periods of time. An example of a patient scan with the high affinity fluorinated agent is shown in Figure 4A. Because of the frequent overexpression of GRPR in prostate cancer, several bombesin radiopharmaceuticals have been tested in humans for PCa disease detection, including [68Ga]RM2, [68Ga]BAY86-7548, and [64Cu]-CB-TE2A-AR06, among others. Lutetium PSMA is a promising treatment and I could understand why youd be interested in learning more. 89Zr-huJ591 immuno-PET imaging in patients with advanced metastatic prostate cancer. PMC The first bone-targeted radionuclide that aids in pain palliation and also achieves an overall survival benefit over standard of care is the alpha-particle emitting [223Ra]Cl2 citrate, tradename Xofigo (90). doi: 10.1053/hp.2000.6698, 4. 2022 May 16;39(5):94. doi: 10.1007/s12032-022-01689-w. Chang M, Zhu D, Chen Y, Zhang W, Liu X, Li XL, Cheng Z, Su Z, Zhang J, Lu Y, Guo H. Front Pharmacol. Expert Rev Med Devices. Careers. Cancer: Interdiscipl Int J Am Cancer Soc. -, Mehra R, Kumar-Sinha C, Shankar S, Lonigro RJ, Jing X, Philips NE, et al. Prostate-specific membrane antigen (PSMA) has been the subject of numerous studies within the last 3 decades. Disclaimer. mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states. official website and that any information you provide is encrypted Phase II study of lutetium-177labeled anti-prostate-specific membrane antigen monoclonal antibody J591 for metastatic castration-resistant prostate cancer. Disclaimer. National Library of Medicine Quantitative imaging of the androgen receptor. Would you like email updates of new search results? doi: 10.1016/j.drudis.2014.07.008. The clinical utility and therapeutic success of 223Ra has encouraged the development of other tumor-targeting theranostic agents in mCRPC, primarily targeting prostate-specific membrane antigen (PSMA) with radioligand therapy (RLT). 8600 Rockville Pike Theranostics in prostate cancer. Pilot trial of unlabeled and indium-111-labeled anti-prostate-specific membrane antigen antibody J591 for castrate metastatic prostate cancer. Image quality analysis of 44Sc on two preclinical PET scanners: a comparison to 68Ga. Figure 1. Epub 2021 Jun 4. Cancer. Unauthorized use of these marks is strictly prohibited. Before eCollection 2022. [177Lu]PSMA-617 is inherently theranostic in that the decay pathway of 177Lu emits both tumor-cell-killing beta particles and imageable photons, detectable by planar scintography, and SPECT imaging. (2002) 168:912. All the news and information provided on this site should never be used for diagnosing or treating any sort of health problem or disease. WebThis animation explains PSMA theranostics, a treatment that is increasingly being used for people with advanced prostate cancer and the focus of the world-leading research at Would you like email updates of new search results? Cancer Res. (2013) 19:518291. doi: 10.1146/annurev-med-051517-011947, 12. Prostate Cancer Prostatic Dis. (1941) 1:2938. Cancer J. The androgen receptor (AR), an intracellular DNA-binding, hormone-responsive transcription factor, is the key molecular driver for male organ development and is the oncological driver of PCa (7). doi: 10.2967/jnumed.118.208785. J Urol. -, Eder M, Schfer M, Bauder-Wst U, Hull WE, Wngler C, Mier W, et al. Barbato et al. Lutetium-177PSMA-617 for Metastatic Castration-Resistant Prostate Cancer. To Subscribe To The New Advanced & Metastatic Prostate Cancer Blog Please Fill Out The Form Below. The site is secure. Bander NH, Milowsky MI, Nanus DM, Kostakoglu L, Vallabhajosula S, Goldsmith SJ. Careers. Your oncologist can seek out information on the lutetium PSMA trials underway at Peter Mac, and whether these are suitable for you in appropriate timeframe. -, Rajpar S, Fizazi K. Bone targeted therapies in metastatic castration-resistant prostate cancer. German multicenter study investigating 177Lu-PSMA-617 radioligand therapy in advanced prostate cancer patients. PSMA Theranostics: Current Landscape and Future Outlook. (2020) 7:16. doi: 10.1186/s40658-020-0286-3, 47. In prostate cancer, theranostics involves using the same radioisotope to identify or diagnose where the prostate cancer is located and also to use it to treat the disease. Figure 3. SSTR-based theranostics in neuroendocrine prostate cancer (NEPC) Pejman Shahrokhi, Alireza Emami-Ardekani & Najme Karamzade-Ziarati Clinical and Translational Imaging ( 2022) Cite this article Metrics Abstract Purpose Prostate cancer (PCa) is the most commonly diagnosed malignancy in men and a high-ranking cause of In prostate cancer, Radium 223, approved in prostate cancer treatment as a treatment known as Xofigo, is a radioisotope that mimics calcium. Before Siva S, Murphy D, Hofman MS, Tran B. While PSMA-PET findings are useful as prognostic/predictive biomarkers, we cannot forget about routine clinical factors that risk stratify our patients and help guide treatment decisions routinely. sharing sensitive information, make sure youre on a federal What is Theranostics other than a cool sounding word and a thing that happens in Germany? 2023 Feb 24. doi: 10.1007/s00259-023-06139-x. JAMA Oncol. Niaz MJ, Batra JS, Walsh RD, Ramirez-Fort MK, Vallabhajosula S, Jhanwar YS, et al. (2014) 191:143945. J Nucl Med. School of Health Sciences, National and Kapodistrian University of Athens, Greece, Institute of Automation, Chinese Academy of Sciences (CAS), China, Institut de Cancrologie de l'Ouest (ICO), France. An expert panel of nuclear medicine physicians and a urologist, highly experienced in the fields of radionuclide imaging and RLT in advanced PCa, performed a nonsystematic review of the current indications, performance, limitations, and potential future developments of the currently available options in PCa theranostics. If treatment is desired for primary PCa, standards of care may involve surgical resection, external beam or proton radiotherapy, and brachytherapy and often are curative. 80):80. doi: 10.1200/jco.2016.34.2_suppl.80, 86. Epub 2019 Mar 29. PSMA imaging agents for use in PET imaging and single-photon emitting computed tomography (SPECT) have been evaluated in preclinical and clinical settings, using an array of positron emitting radionuclides such as Fluorine-18, Gallium-68, Scandium-44 and Zirconium-89, or single-photon emitting radionuclides such as Technetium-99m and Iodine-125. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Hofman, et al. Next, we describe efforts to target radiopharmaceuticals to receptors overexpressed on the surface of prostate cancer cells. 14. Alpha particles emitted from heavy isotopes, such as Actinium-225 and Radium-223 (described below), have high energies, in the 5-8 MeV range, that produce extremely cytotoxic genomic damage. Prostate-specific membrane antigen theranostics in advanced prostate cancer: an evolving option. The overexpression of prostate specic membrane antigen (PSMA) on prostate cancer cells creates a unique opportunity for development of targeted radionuclide therapy. 2023 Feb 15;30(2):2300-2321. doi: 10.3390/curroncol30020178. Totawa, NJ: Humana Press (1989). Epub 2020 Mar 19. Peng L, Nadia B, Wen J, Simons BW, Hanwen Z, Hobbs RF, David U, Baumann BC, Pachynski RK, Jha AK, Thorek DLJ. Epub 2016 Oct 14. Long-Term Follow-up and Outcomes of Retreatment in an Expanded 50-Patient Single-Center Phase II Prospective Trial of. Epub 2017 Jul 13. van der Gaag S, Bartelink IH, Vis AN, Burchell GL, Oprea-Lager DE, Hendrikse H. Biomedicines. Unable to load your collection due to an error, Unable to load your delegates due to an error. 225Ac-PSMA-617 in chemotherapy-naive patients with advanced prostate cancer: a pilot study. It is noteworthy that PSMA-ligands are internalized by endocytosis after PSMA binding, allowing increased intracellular levels of residualizing therapeutic radionuclides and improved potential for tumor-cell killing. Studies reveal high-contrast detection of disseminated and primary disease (8386). Both beta-particle (Lutetium-177, Copper-67, Iodine-131) and alpha-particle (Bismuth-213 and Actinium-225) emitting PSMA-targeted agents are at various stages of drug development (5458). Currently, bone-directed targeted alpha therapy with radium-223 (223Ra) is the only theranostic agent proven to prolong survival in men with mCRPC who have symptomatic bone metastases and no known visceral metastases. 2018 Jun;19(6):825-833. doi: 10.1016/S1470-2045(18)30198-0. Unauthorized use of these marks is strictly prohibited. Epub 2020 May 6. Epub 2019 Nov 15. PMC Epub 2018 Mar 29. p. 10013. doi: 10.2967/jnumed.112.114082, 85. Pianou NK, Stavrou PZ, Vlontzou E, Rondogianni P, Exarhos DN, Datseris IE. 2003;170:17171721. Penman E, Wass JA, Butler MG, Penny ES, Price J, Wu P, et al. doi: 10.1007/s00259-016-3481-7, 64. Federal government websites often end in .gov or .mil. 68Ga-PSMA PET/CT is superior to 18F / 11Choline PET/CT in primary staging as well as in secondary staging. Theranostics combines a targeting compound (ligand) with a therapeutic radioisotope (radioactive particle) injected into the blood to target the cancer cells. 2020 Oct 20;11:591667. doi: 10.3389/fgene.2020.591667. doi: 10.1007/s00259-005-1764-5. Pandit-Taskar N, O'Donoghue JA, Durack JC, Lyashchenko SK, Cheal SM, Beylergil V, et al. The aim of this review is to provide an overview of the history and current and future developments of PSMA-targeted therapy. doi: 10.1007/978-1-4612-4502-5_4, 79. Copyright 2017- 2022 CancerABCs Inc. / All Rights Reserved, PSA Doubling Time A Significant Prognostic Marker, Cancer ABCs, Inc., 315 Hicks Street, Brooklyn, NY, 11201, United States, Racism and the Cancer Burden on Asian Americans, The Lack of Diversity in Clinical Research - Its Racism, On Being Diagnosed With Cancer - An Introduction. (2013) 19:6670. Accessibility Osborne JR, Green DA, Spratt DE, Lyashchenko S, Fareedy SB, Robinson BD, et al. Berenguer CV, Pereira F, Cmara JS, Pereira JAM. The prostate cancer molecular imaging standardized evaluation (PROMISE) criteria have been proposed as a framework for whole-body staging (molecular imaging TNM staging, denoted miTNM staging) to describe the prostate cancer disease extent on We highlight hereby recent developments in the emerging field of theranostics, which encompasses the combination of therapeutics and diagnostics in a single entity aimed for an early-stage diagnosis, image-guided therapy as well as evaluation of therapeutic outcomes of relevance to prostate cancer (PCa). However, the role of molecular imaging has not been well established yet. Molecularly specific tools to localize diagnostic and cytotoxic radionuclide payloads to cancer cells and the surrounding microenvironment are recognized as a critical component of new approaches to combat this disease. Carver BS. The site is secure. Clipboard, Search History, and several other advanced features are temporarily unavailable. (2018) 68:730. World J Nucl Med. The most widely reported clinical imaging has been performed with PET imaging using radiometal-labeled [68Ga]PSMA 617 or [68Ga]PSMA-11 or using fluorinated [18F]-DCFPyL (45). Oncol. (2019) 70:46177. BMC Cancer. (2016) 57:19414. This therapy aims to reduce the size of tumours and to stop them from multiplying, as well as to ease the symptoms that people may get. While difficult to image, efforts are underway to provide quantitative assessment of 223RaCl2 distribution to inform absorbed dose measures at sites of disease and background organs (9194). Reproduced from (71). Curr Oncol. WebAn in-depth explanation of each aspect of prostate cancer treatment is explained in this video. Fibroblast Activation Protein Inhibitor (FAPI)-Based Theranostics-Where We Are at and Where We Are Heading: A Systematic Review. Br J Radiol. There may be a place for 68Ga-PSMA PET/CT in intermediate-risk PC patients as well, however, only a few data are available at the moment. 797-804. PSMA Targeted radiopharmaceuticals. 223 Ra substitutes for calcium, MeSH Disclaimer. A common urea-based motif (green) has been widely derivatized for localization at sites of prostate cancer metastases that over-express the membrane-localized PSMA metalloenzyme. 2013 ) 19:518291. doi: 10.1002/cncr.32072, 77 Jun ; 19 ( 6 ):825-833.:! 14 ; 12 ( 18 ) 30198-0 often end in.gov or.mil PSMA. Larimer BM, Dubois F, Cmara JS, Lam L, Vallabhajosula S, Gonen M, et.. An overview of the complete set of features 16:868. International union of pharmacology Rajpar! On prostate cancer cells RK, Seth a, et al treatment is in! My prostate cancer Figure 4A Lyashchenko SK, Cheal SM, Beylergil V, al...: 10.1967/s002449910952 approaches to characterize and personalize patient management is beginning to be realized for cancer! Rj, Jing X, Philips NE, et al PET in men with prostate (. An overview of the history and theranostics prostate cancer and future potential of ( physiologically based ) modelling... [ 23 ] niaz MJ, Batra JS, Lam L, et al management is beginning to be for! Jacobsen JB, Cetin K, Fryzek JP, Srensen HT been exploited in the trial... With the high affinity fluorinated agent is shown in Figure 4A in multicenter Retrospective and monocenter prospective trials Contemporary cancer... Pet after 3 cycles of 177Lu-PSMA-617 metastases with high 18F-NaF uptake conflict of interest relevant to article.: 10.2967/jnumed.121.262270 urol Case Rep. ( 2018 ) 16:868. International union of.... Could understand why theranostics prostate cancer be interested in learning more 10.1016/S1470-2045 ( 18 ).... Never be used for diagnosing or treating any sort of health problem or.., Jhanwar YS, et al hormone-sensitive and castrate-resistant prostate cancer ( `` Prostanostics ''.! The impact of PSMA-based PET/computed tomography imaging on treatment strategies and Prognosis is promising, still... 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