Some time later, Wang found a reference to diethylene glycol in a chemical book. OSHA - TABLE Z -1 Limits for Air Contaminants - 1910.1000 C 100 mg/m3 USA. Still, false positives and negatives often occur. If you do not agree with these terms and conditions, please disconnect immediately from this website. For CHEMTREC assistance, call: 800-424-9300 + [glucose divided by 18] Zhang H, Liu X, Wu F, Qin F, Feng P, Xu T, Li X, Yang L. Int J Mol Sci. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). [15] In the case of DEG, observations demonstrated there were no calcium oxalate crystal deposits in the kidneys, implying ethylene glycol is not on the DEG metabolic pathway. Nu, doresc s rmn pe site-ul actual. Unable to load your collection due to an error, Unable to load your delegates due to an error. Nearly half of the victims were under the age of two. Shortly after, 2-hydroxyethoxyacetaldehyde (C4H8O3) is metabolized by the enzyme aldehyde dehydrogenase (ALDH) into the weak acid 2-hydroxyethoxyacetic acid (HEAA) with chemical formula C4H8O4. Blindness and pink edematous optic disk (delayed findings), Ethylene glycol poisoning is strongly suggested by. HI96831 Hanna Instruments. Material Safety Data Sheet or SDS for Ethylene glycol 100949 from Merck for download or viewing in the browser. If you are not able to see the SDS please use this link to download it: Download SDS Research. Development. Production. The industry generally operates to maximize MEG production. Soon, patients from other parts of the country started to arrive at hospitals. This paper reported a facile strategy for the one-pot synthesis of vinyl sulfone (VS) group terminated hydrogel precursors [poly(ethylene) glycol (PEG)-VS] and PEG hydrogels via catalytic oxa-Michael reaction. Engineering of amphiphilic block copolymers for polymeric micellar drug and gene delivery. glycol monoethyl ether acetate; EGEEA; Ethylene glycol ethyl ether In November, The New York Times published a wine recall that the Federal Government released after the Bureau of Alcohol, Tobacco and Firearms tested 1,000 bottles. [43] Immediately, biological samples and the syrup were sent by jet to CDC for analysis. CE Expiration Date: March 20, 2024 If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. (b), Increase in the amount of glycerol in the reactant led to the increase, FITC-BSA adsorption on the PEG hydrogels prepared with different ratios of glycerol to, Viability of the cells with PEG hydrogel treatment normalized to the untreated control, Cumulative release of Nile Red (a) and oleanic acid (b) from hydrogels prepared, MeSH The company tested the new product, Elixir sulfanilamide, for viscosity, appearance and fragrance. Company Identification: The study revealed a strong association between ingestion of two locally produced acetaminophen liquid products (Afebril and Valodon) and illness. The site is secure. However, potentially toxic serum concentrations of ethylene glycol (2030 mg/dL) do not always produce early symptoms in children or adults. DEG: why it more hazardous to humans, than animals? May cause respiratory tract irritation. [5] DEG is used as a building block in organic synthesis, e.g. : 111-90-0 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, Synthesis of substances 1.3 Details of the supplier of the safety data sheet Company : Sigma-Aldrich Inc. It was not until September 1996 that Sinochem provided a name of the manufacturer of the tainted syrup. Agency for Toxic Substance and Disease Registration, Ethylene Glycol and Propylene Glycol Toxicity, Agency for Toxic Substances and Disease Registry. Inhalation: Ingestion of large >> WebSAFETY DATA SHEET SDS00349 ETHYLENEGLYCOL Preparation Date: 25/Jun/2020 Version: 4 1. Measurement of serum ethylene glycol levels can confirm poisoning. xwTS7PkhRH H. stream J Control Release. "Counterfeit Colgate Toothpaste Found", June 14, 2007. Bethesda, MD 20894, Web Policies WebEDTA - Ethylene Diamine TetraAcetic Acid is a transparent water soluble belonging to a class of chelators that bind-chelate-metals. Epub 2016 Sep 11. WebBiomass Laboratory, School of Chemistry, University of Costa Rica, Ciudad Universitaria Rodrigo Facio, San Pedro 11501-2060, Costa Rica Evapn. May cause << This triggered the installation of more sensitive laboratory equipment in Banafi laboratories, Italy, and stronger alcohol regulations in Austria. 4 0 obj Thio-oxalic acid o,s-dimethyl ester 1-oxime 23135-20-8 . The poison had caused the death of at least 84 Nigerian children between ages of two months and seven years. A dilute solution of diethylene glycol can also be used as a cryoprotectant; however, ethylene glycol is much more commonly used. May be harmful if swallowed, inhaled, or absorbed through [59][60] Although there were no reports of anyone harmed, several people in the eastern US reported experiencing headaches and pain after using the product. They also arrested 12 people in connection with the incident. Emergency Number: 201-796-7100 [BAT (ethanol) divided by 4.6 (if present)], OG = osmolality (measured)* One year and a half after the FDA began to trace the poisonous shipments, an inspector, Ted Sze, finally visited the Tianhong Fine Chemicals Factory in Dalian, northeastern China. [52], In May 2007, a Panamanian named Eduardo Arias discovered a 59-cent toothpaste that was labeled containing DEG. 2011]. Diethylene glycol (DEG) is an organic compound with the formula (HOCH2CH2)2O. During the month of July 1985, Austrian wines were found to contain up to 1,000 parts per million of DEG, giving them a desirable sweetness. [41] As a result of the case-control findings, and subsequent investigation at the factory, public warnings were issued by the Ministry of Health and bottles of the two medications were taken from pharmacy shelves and destroyed. In such cases, an elevated anion-gap metabolic acidosis will take longer to develop than if ethylene glycol alone were ingested. [43], Ending September 2006, the Arnulfo Arias Madrid Hospital at Panama City was getting full with patients with contradictory symptoms. The presence of metabolic acidosis with anion and osmolal gaps is an important clue to the diagnosis (Friedman et al. An official website of the United States government. [33] The United States Food and Drug Administration also issued an Industry Guidance Document "intended to alert pharmaceutical manufacturers, pharmacy compounders, repackers, and suppliers to the potential public health hazard of glycerin contaminated with diethylene glycol (DEG)" and recommended appropriate testing procedures for the use of glycerin. WebDiethylene glycol ethyl ether Formula : C 6 H 14 O 3 Molecular weight : 134.17 g/mol CAS-No. official website and that any information you provide is encrypted At the time, the food and drug laws did not require toxicological analysis before releasing for sale. Federal government websites often end in .gov or .mil. They help us to know which pages are the most and least popular and see how visitors move around the site. The information provided in this Material Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The glycol scale used is based upon the relationship between concentration and RI for two component mixtures of ethylene of propylene in water. Your continued use of this site indicates your acceptance of the terms and conditions specified. In experiments with laboratory animals, EGEEA has caused developmental abnormalities in the musculoskeletal, respiratory, cardiovascular, and urogenital systems. This site needs JavaScript to work properly. Patients who survive but develop kidney failure remain dialysis-dependent. It is also used in hydraulic brake fluids and inks used in stamp pads, ballpoint pens, and print shops. Misiak P, Markiewicz KH, Szymczuk D, Wilczewska AZ. It is a solvent for nitrocellulose, resins, dyes, oils, and other organic compounds. Epub 2010 Jan 7. [2], DEG is produced by the partial hydrolysis of ethylene oxide. This material has been reported to be Epub 2017 Dec 12. : 111-90-0 EC-No. "R}~Q:~pgg'"l/O:OV~ @zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#w6"egHf_O='i>.xxpo]"a]f&&CY]_[LH=)>~O4v{x?StuS)F;Nf-iLn}tfi7_2O?/U~Q-.S&wy67ON2e5N}s0?zby?~M@tw~`__/ 1. Because patients treated with Lisinopril developed a cough (a common side effect of ACE inhibitors), they were prescribed an expectorant. WebEthylene Glycol; Laboratory; Fisher Chemical; 20L; Steel Pail; 1,2-Ethanediol; F.W. The most commonly used analytic methods for detection and quantification of ethylene glycol use gas chromatography (GC) coupled to flame ionization detection (FID) or mass spectrometric detectors [Juenke et al. The Himachal Pradesh government is filing a criminal case against the company and its executives.[75][76]. [53][54][55] For the end of the month, the Chinese government committed to investigate the "supposedly" tainted toothpaste that had been recalled in Panama and Dominican Republic, but stated that, as per an essay written in 2000, a toothpaste containing 15.6% was not dangerous. of acute inhalation and ingestion. system, liver, reproductive system. May cause skin irritation. birth defects based on animal data. Download Printer-Friendly version [PDF 954 KB], After completing this section, you will be able to. ;gkUKT+km)i5is8ME*lXL_:Or#R" Yu4 l ~6,BZ)*8,qD~\cd~v .C1c-D;mr\ 2Uc53.~=#uj+pDl>HRhg)}r3RgV]Q(2:. [44] The 46 barrels of syrup were bought by Social Security Laboratories through a Panamanian middleman, Grupo Comercial Medicom, who bought the product from Rasfer Internacional, a Spanish company. WebMaterial Safety Data Sheet Version 5.0 Revision Date 04/21/2012 Print Date 05/23/2012 1. : 110-80-5 Product code : LC14160 Formula : C4H10O2 . Eclipse refractometers areMade in the UK by Bellingham & Stanley and recognised as one of the worlds most reliable and robust optical refractometers on the market today. amounts may cause CNS depression. Potential Health Effects vapor. DEG is a widely used solvent. The resulting product is two ethylene glycol molecules joined by an ether bond. It is miscible in water, alcohol, ether, acetone, and ethylene glycol. If alcoholic ketoacidosis is suspected, serum lactate and -hydroxybutyrate levels might help identify alcoholic patients. Target Organs: Blood, kidneys, central nervous liver and kidney damage. Dorii s schimbai site-ul? This paper reported a facile strategy for the one-pot synthesis of vinyl sulfone (VS) group terminated hydrogel precursors [poly(ethylene) glycol (PEG)-VS] and PEG hydrogels via catalytic oxa-Michael reaction. PMC Between November 1995 and June 1996, almost 109 children admitted to the University Hospital in Port-au-Prince, Haiti, presented with acute kidney failure. Vapors may cause dizziness or suffocation. [2][23], Patients being treated for burns developed sudden anuric kidney failure. effects characterized by nausea, headache, dizziness, unconsciousness LabChem Inc HHS Vulnerability Disclosure, Help WebProduct name : Propylene Glycol Product Number : P4347 Brand : Sigma-Aldrich CAS-No. 2007 Sep 11;122(1):71-8. doi: 10.1016/j.jconrel.2007.06.011. Chronic inhalation and ingestion may cause effects similar to those EDTA is a sequestering agent of high purity forming stable, water-soluble chelats with polyvalent metal ions in a wide pH range. [2] DEG is a widely used solvent. Some wines contained less than 10 parts per million of DEG, a small amount that could not be detected by laboratory analysis in Europe. Polymers (Basel). endobj 2010). WebETHYLENE - C 2H 4 MSDS (Document # 001022) PAGE 1 OF 9 MATERIAL SAFETY DATA SHEET Prepared to U.S. OSHA, CMA, ANSI and Canadian WHMIS Standards All hazard information pertinent to this gas has been provided in this Material Safety Data Sheet, per the requirements of the OSHA Hazard Communication Standard (29 CFR CE Original Date: March 20, 2020 Would you like email updates of new search results? Everyone is encouraged to see their own healthcare professional to review what is best for them. Calcium oxalate or hippurate crystals in the urine, together with an elevated anion gap or osmolal gap, strongly suggest ethylene glycol poisoning (Albertson 1999). [11], Diethylene glycol has "moderate to low" acute toxicity[12] in animal experiments. Results of this test are used to calculate the osmolal gap (Figure 2). [74] The investigation revealed that DEG had been used as a coolant for the brewery equipment, in what should have been a closed circuit, but an undetected leak in the system contaminated some batches of beer. Seventeen other persons have also been charged related to this incident. Product Technical Specification: Specifications of Disodium EDTA In April 2006, the Guangdong Province Hospital of Guangzhou began administering Amillarisin A to their patients. sLYa"0TBZa/"T/z0lhk!6G5ns`Pf;j8+}s 85h]UF@]^SGNSSn3ade$cf>1zCr8zDED"nm( +^"y(gXJ70FG hz*&h9] `O@j$3.#fCH8`\x [P4we.xtm]6$UAVO j`~4D.9jr|#1e.Nu{]H9 Gj?L{FbgAn+` 7`}d}3" fP,g ,Gn TnC"*z7VO6 xJ }&rC%F*an)&b-PfB^Wughfb8@,_be]+>7igOJv=k_{k2Il{"YR #mJfW5OathjrWQ=w 1988). Once physicians identified a suspect paracetamol syrup, samples were shipped to the Centers for Disease Control and Prevention (CDC) in the U.S., which identified DEG. [51], During June 2011, the number of confirmed deaths according to the official list rose to 219 victims. 2016 Dec;27(17):1698-1711. doi: 10.1080/09205063.2016.1230933. "FDA Advises Consumers to Avoid Toothpaste From China Containing Harmful Chemical. National Library of Medicine : E181-4 Synonyms Oxitol acetate; 2-Ethoxyethyl acetate; Cellosolve acetate Recommended Use Laboratory chemicals.